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Thesis Summary



TITLE:

          Phytochemical and Pharmacogistical studies on Some Indian Medicinal Plants.


Subject : Chemistry
Department : Chemistry
Name of the student : Syed Tarique Abdullah
Name of the supervisor : Dr. M.S. Alam
Date of Viva Voce : 24th December 2002


Summary

The present research work involves isolation and characterization of twenty-six compounds, including nineteen new compounds isolated from the extracts of three different plants, their standardization and biological evaluation for their anti-inflammatory and antibacterial activities.

Parmelia perlata Ach. A lichen of family Parmaleaceae, known for its emollient, tonic, febrifuge, diuretic, demulcent and sedative properties yielded

Ø29, 30-nordimethyl-lanost-2-ene, named parmelialanostene

Ønaphtha-4-(4¢-methylbutan-4¢-olyl)-6-methyl-8,9-diol-1-one,named parmenaphthone A

Ø3-ethyl-6-methyl-7-carboxy-8-hydroxymethylene-9-hydroxy-naphtha-1-one, named parmenaphthone B

Ø3-(pentdienyl)-2,5-dimethyl-11-aldehydic-13-hydroxymethylene-10,12-dimethoxy stilbene, named Parmenal

Ø4¢-hydroxy-5¢-methyl-1¢-pyrogallolyl-(2-formyl-3-hydroxy-4,5-dimethyl) benzoate, named parmelyl ester A

Ø4¢-methylcarboxy-3¢-hydroxy-2¢,5¢-dimethyl-1¢-phenyl-(3-aldehydic-2,4-dihydroxy-6-methyl) benzoate, named Atranorin.

Ø4¢-methylcarboxy-3¢, 5¢-dihydroxy-2¢-methyl-1¢-phenyl (3-aldehydic-4-hydroxy-2,6-dimethyl) benzoate, named parmelyl ester B

ØLup-20(29)-en-3a,27-diol, named parmelupenol A

ØLup-20(29)-en-3a,28-diol, named parmelupenol B

Ø16,18-normethyllabdone-18-(3¢-O-methoxy-benzoyloxy)-O-methoxypyrocatechol, named parmelabdone

Øb-3-(deca-11-one-yl)-5-methoxy-pyrogalloyl-(2¢,7¢-dihydroxy-5¢-methoxy) naphthyl ether, named parmenone.

Rubia cordifolia Linn. The plant has antioxidant, antihaemorrhagic, hepatotoxic, antineoplastic, antiallergenic, antibacterial and antiviral properties. Dried roots are considered to be useful in alleviating dropsy, paralysis, jaundice, amenorrhoa and visceral obstruction. It exerts uricolytic activities and thus promotes disintegration as well as elimination of urinary stone. The plant yielded

Ø 1-hydroxy-3-carboxy-6-ethyl-9, 10-anthraquinone, named as Cordifoloic acid

Ø 1,3-dihydroxy-2-methyl-9, 10-anthraquinone, named Rubiadin.

Ø 1,3-dihydroxy-9, 10-anthraquinone, named Xanthopurpurin

Ø 1, 2-dihydroxy-9, 10-anthraquinone, named Alizarin.

Ø 1-methyl-2, 4-dihydroxy-9, 10-anthraquinone named as Rubiol

Ø Urs- 12- en-3b-ol, 3-epi-a-amyrin

Ø 1-hydroxy-3-ethyl-9, 10-anthraquinone, named as Cordifoliol

Ø 1,8-dihydroxy-11,20 (15-Pentyl- naphthaquinonyl) phenanthranene, named Cordifodiol.

Rumex maritimus Linn. The plant has refrigerant, antipyretic, cathartic and aphrodisiac activity. It has been used to treat burns and back pain and the alcoholic extract has antifungal activity against Trichophyton mentagrophytes and Micospermum canis.

The plant yielded

Ø n-dotriacont-3-one, named as Maritimone

Ø n-heptacos-18,20,22-trien-1-ol, named as Rumexenol,

Ø 22-n- hexyl-12-(a-tetradecahydroanthracenyl)-undecan-3-ol-1-oic acid, named as Rumexoic acid

Ø quercetin

Ø sitosterol glycoside

Ø 3,7,11,15-tetramethyl-n-octadac-13-en-3,4,6,7,8,11-hexol-12-one, named as Rumexenone

Ø 8-normethyl-16-(19,22-dimethyl-19,22-dihydroxy-heptanyl)-spongiene-5-en-7-on-8-ol-22-b-glucopyranosyl-b-D-glucopyranoside, named as Maritiaspongiene.

Different extracts of these plants exhibited significant anti-inflammatory and anti- bacterial activity against staphylococcus aureus (G+).

Standardization parameters included morphological and microscopical characters, Physiochemical properties and TLC fingerprints.